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Article

Ryanodine receptors, FKBP12, and heart failure.

Frontiers in bioscience : a journal and virtual library - 1 Apr 2002

Marks Andrew R

Abstract excerpt

RyR2 function is regulated by highly conserved signaling pathways that modulate excitation-contraction (EC) coupling. cAMP dependent protein kinase (PKA) phosphorylation of RyR2 plays an important role in regulating channel function in response to stress signaled by the sympathetic nervous system (the classic "fight or flight response") (1). PKA phosphorylation of RyR2 induces dissociation of the regulatory...

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Source

Identifiers

PMID: 11897558
DOI: 10.2741/A822

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Ryanodine receptors, FKBP12, and heart failure.PMID 11897558Read ↗

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Mechanisms of Disease: ryanodine receptor defects in heart failure and fatal arrhythmia.Semantic proximity Read ↗

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Ryanodine receptor channelopathies.Semantic proximity Read ↗

Role of Ca2+ in healthy and pathologic cardiac function: from normal excitation-contraction coupling to mutations that cause inherited arrhythmia.Semantic proximity Read ↗

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