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Article

Loss of Rad-GTPase produces a novel adaptive cardiac phenotype resistant to systolic decline with aging.

American journal of physiology. Heart and circulatory physiology - 1 Oct 2015

Manning Janet R, Withers Catherine N, Levitan Bryana, Smith Jeffrey D, Andres Douglas A, Satin Jonathan

Abstract excerpt

Rad-GTPase is a regulator of L-type calcium current (LTCC), with increased calcium current observed in Rad knockout models. While mouse models that result in elevated LTCC have been associated with heart failure, our laboratory and others observe a hypercontractile phenotype with enhanced calcium homeostasis in Rad(-/-). It is currently unclear whether this observation represents an early time point in a...

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Identifiers

PMID: 26371164
DOI: 10.1152/ajpheart.00389.2015
PMCID: PMC4631537

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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