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Article

β-adrenergic signaling inhibits Gq-dependent protein kinase D activation by preventing protein kinase D translocation.

Circulation research - 25 Apr 2014

Nichols C Blake, Chang Chia-Wei, Ferrero Maura, Wood Brent M, Stein Matthew L, Ferguson Amanda J, Ha Derrick, Rigor Robert R, Bossuyt Sven, Bossuyt Julie

Abstract excerpt

RATIONALE: Both β-adrenergic receptor (β-AR) and Gq-coupled receptor (GqR) agonist-driven signaling play key roles in the events, leading up to and during cardiac dysfunction. How these stimuli interact at the level of protein kinase D (PKD), a nodal point in cardiac hypertrophic signaling, remains unclear. OBJECTIVE: To assess the spatiotemporal dynamics of PKD activation in response to β-AR signaling alone and...

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Share to Adrenergic beta-Agonists
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic AMP-Dependent Protein Kinases

Share to Fluorescence Resonance Energy Transfer

Share to GTP-Binding Protein alpha Subunits, Gq-G11

Share to Myocytes, Cardiac

Share to Protein Kinase C

Share to Receptors, Adrenergic, beta

Source

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Identifiers

PMID: 24643961
DOI: 10.1161/CIRCRESAHA.114.303870
PMCID: PMC4031034

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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