Article
The Role of WNT Pathway Mutations in Cancer Development and an Overview of Therapeutic Options.
Cells - 24 Mar 2023
Groenewald Wibke, Lund Anders H, Gay David Michael
Abstract excerpt
It is well established that mutations in the canonical WNT-signalling pathway play a major role in various cancers. Critical to developing new therapeutic strategies is understanding which cancers are driven by WNT pathway activation and at what level these mutations occur within the pathway. Some cancers harbour mutations in genes whose protein products operate at the receptor level of the WNT pathway. For...
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