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Wnt-Independent and Wnt-Dependent Effects of APC Loss on the Chemotherapeutic Response

22 Oct 2020

Abstract excerpt

Resistance to chemotherapy occurs through mechanisms within the epithelial tumor cells or through interactions with components of the tumor microenvironment (TME). Chemoresistance and the development of recurrent tumors are two of the leading factors of cancer-related deaths. The Adenomatous Polyposis Coli (APC) tumor suppressor is lost in many different cancers, including colorectal, breast, and prostate cancer,...

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PMID: 33105836
DOI: 10.3390/ijms21217844

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