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Article

Network-based identification of key master regulators associated with an immune-silent cancer phenotype.

Briefings in bioinformatics - 5 Nov 2021

Mall Raghvendra, Saad Mohamad, Roelands Jessica, Rinchai Darawan, Kunji Khalid, Almeer Hossam, Hendrickx Wouter, M Marincola Francesco, Ceccarelli Michele, Bedognetti Davide

Abstract excerpt

A cancer immune phenotype characterized by an active T-helper 1 (Th1)/cytotoxic response is associated with responsiveness to immunotherapy and favorable prognosis across different tumors. However, in some cancers, such an intratumoral immune activation does not confer protection from progression or relapse. Defining mechanisms associated with immune evasion is imperative to refine stratification algorithms, to...

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PMID: 33979427
DOI: 10.1093/bib/bbab168
PMCID: PMC8574720

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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