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Small Gene Networks Delineate Immune Cell States and Characterize Immunotherapy Response in Melanoma

25 May 2023

Abstract excerpt

Single-cell technologies have elucidated mechanisms responsible for immune checkpoint inhibitor (ICI) response, but are not amenable to a clinical diagnostic setting. In contrast, bulk RNA sequencing (RNA-seq) is now routine for research and clinical applications. Our workflow uses transcription factor (TF)-directed coexpression networks (regulons) inferred from single-cell RNA-seq data to deconvolute immune...

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PMID: 37229623
DOI: 10.1158/2326-6066.cir-22-0563

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