Article

A LRRK2/dLRRK-mediated lysosomal pathway that contributes to glial cell death and DA neuron survival

2021-11-25

Abstract excerpt

Mutations in leucine-rich repeat kinase 2 ( LRRK2 ) are the most common cause of familial and sporadic Parkinson’s disease (PD). A plethora of evidence has indicated a role for LRRK2 in endolysosomal trafficking in neurons, while LRRK2 function in glia, although highly expressed, remains largely unknown. Here we present evidence that LRRK2/dLRRK mediates a glial lysosomal pathway that contributes to the mechanis...

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Literature Corpus work: 27d3005c-1d04-5789-8ec9-8285443ede0e
DOI: 10.1101/2021.11.25.469972

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