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Article

B cell pathways implicate shared genetic architecture between schizophrenia and immune-mediated diseases.

Journal of translational medicine - 14 Jan 2026

Yuan Rui, Zhu Yunqing, Zhang Yuyanan, Sun Yaoyao, Lu Zhe, Kang Zhewei, Feng Xiaoyang, Sun Junyuan, Zhao Guorui, Guo Jing, Yu Tong, Bi Wenjian, Yue Weihua

Abstract excerpt

BACKGROUND: Schizophrenia and immune-mediated diseases are globally prevalent and highly heritable conditions that frequently co-occur, posing major public health burdens. However, their shared genetic architecture remains poorly understood. METHODS: We applied the bivariate causal mixture model (MiXeR) to investigate the polygenic overlap between schizophrenia and eight common immune-mediated diseases, using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41535972
DOI: 10.1186/s12967-025-07667-w
PMCID: PMC12888748

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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