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Article

Identification of germ cell-specific Mga variant mRNA that promotes meiosis via impediment of a non-canonical PRC1.

Scientific reports - 6 May 2021

Kitamura Yuka, Uranishi Kousuke, Hirasaki Masataka, Nishimoto Masazumi, Suzuki Ayumu, Okuda Akihiko

Abstract excerpt

A non-canonical PRC1 (PRC1.6) prevents precocious meiotic onset. Germ cells alleviate its negative effect by reducing their amount of MAX, a component of PRC1.6, as a prerequisite for their bona fide meiosis. Here, we found that germ cells produced Mga variant mRNA bearing a premature termination codon (PTC) during meiosis as an additional mechanism to impede the function of PRC1.6. The variant mRNA encodes an...

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Identifiers

PMID: 33958653
DOI: 10.1038/s41598-021-89123-5
PMCID: PMC8102552

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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