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Derepression of a Subset of Meiotic Proteins in Primordial Germ Cells of max Mutant Zebrafish.

Development, growth & differentiation - 1 Apr 2026

Hasegawa Yuya, Kawasaki Toshihiro, Imai Yukiko, Matsui Yasuhisa, Sakai Noriyoshi

Abstract excerpt

Germ cells in zebrafish are specified by a preformation mechanism, unlike in mice. Max (Myc associated factor X) and its associated PRC1.6 (polycomb repressive complex 1.6) act as negative regulators of germ cell- and meiosis-related genes in mice; however, their function in zebrafish remains unknown. Here, we generated max mutants in zebrafish using genome-editing techniques to investigate the role of Max in...

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Identifiers

PMID: 41983995
DOI: 10.1111/dgd.70053

Genes

PRC1

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