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Article

Interaction between microRNAs and actin-associated protein Arpc5 regulates translational suppression during male germ cell differentiation

23 Mar 2012

Abstract excerpt

Decoupling of transcription and translation during postmeiotic germ cell differentiation is critical for successful spermatogenesis. Here we establish that the interaction between microRNAs and actin-associated protein Arpc5 sets the stage for an elaborate translational control mechanism by facilitating the sequestration of germ cell mRNAs into translationally inert ribonucleoprotein particles until they are...

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PMID: 22447776
DOI: 10.1073/pnas.1117837109

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