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Polycomb repressive complex 1 modulates granulosa cell proliferation in early folliculogenesis to support female reproduction

1 Jan 2024

Abstract excerpt

Rationale: Premature ovarian insufficiency (POI) is an accelerated reduction in ovarian function inducing infertility. Folliculogenesis defects have been reported to trigger POI as a consequence of ovulation failure. However, the underlying mechanisms remain unclear due to the genetic complexity and heterogeneity of POI. Methods: We used whole genome sequencing (WGS), conditional knockout mouse models combined...

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PMID: 38389850
DOI: 10.7150/thno.89878

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