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Article

Meiosis error and subsequent genetic and epigenetic alterations invoke the malignant transformation of germ cell tumor.

Genes, chromosomes & cancer - 1 Mar 2013

Ichikawa Mizuho, Arai Yasuhito, Haruta Masayuki, Furukawa Shinsuke, Ariga Tadashi, Kajii Tadashi, Kaneko Yasuhiko

Abstract excerpt

Germ cell tumors (GCTs) are thought to arise from primordial germ cells (PGCs) that undergo epigenetic reprogramming. To explore the mechanisms of GCT formation, we analyzed single-nucleotide polymorphism array comparative genomic hybridization patterns and the methylation status of 15 tumor suppressor genes (TSGs) and differentially methylated regions (DMRs) of two imprinted genes, H19 and SNRPN, in 28 children...

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Source

Identifiers

PMID: 23225212
DOI: 10.1002/gcc.22027

Genes

SNRPN
RUNX3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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