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Article

Quantifying the Determinants of Evolutionary Dynamics Leading to Drug Resistance.

PLoS biology - 1 Jan 2015

Chevereau Guillaume, Dravecká Marta, Batur Tugce, Guvenek Aysegul, Ayhan Dilay Hazal, Toprak Erdal, Bollenbach Tobias

Abstract excerpt

The emergence of drug resistant pathogens is a serious public health problem. It is a long-standing goal to predict rates of resistance evolution and design optimal treatment strategies accordingly. To this end, it is crucial to reveal the underlying causes of drug-specific differences in the evolutionary dynamics leading to resistance. However, it remains largely unknown why the rates of resistance evolution via...

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PMID: 26581035
DOI: 10.1371/journal.pbio.1002299
PMCID: PMC4651364

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