Quantifying the Determinants of Evolutionary Dynamics Leading to Drug Resistance.

doi:10.1371/journal.pbio.1002299

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Article

Quantifying the Determinants of Evolutionary Dynamics Leading to Drug Resistance.

PLoS biology - 1 Jan 2015

Chevereau Guillaume, Dravecká Marta, Batur Tugce, Guvenek Aysegul, Ayhan Dilay Hazal, Toprak Erdal, Bollenbach Tobias

Abstract excerpt

The emergence of drug resistant pathogens is a serious public health problem. It is a long-standing goal to predict rates of resistance evolution and design optimal treatment strategies accordingly. To this end, it is crucial to reveal the underlying causes of drug-specific differences in the evolutionary dynamics leading to resistance. However, it remains largely unknown why the rates of resistance evolution via...

Topics

Algorithms
Anti-Bacterial Agents
Drug Resistance, Bacterial
Drug Resistance, Multiple, Bacterial
Escherichia coli
Escherichia coli K12
Escherichia coli Proteins
Evolution, Molecular
Gene Deletion
Genetic Fitness

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microbial Sensitivity Tests

Models, Genetic

Mutagens

Mutation

Mutation Rate

Nitrofurantoin

Reproducibility of Results

Source

Open in PubMed Open full text

Identifiers

PMID: 26581035
DOI: 10.1371/journal.pbio.1002299
PMCID: PMC4651364

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