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Article

The voltage sensor is responsible for ΔpH dependence in Hv1 channels.

Proceedings of the National Academy of Sciences of the United States of America - 11 May 2021

Carmona Emerson M, Fernandez Miguel, Alvear-Arias Juan J, Neely Alan, Larsson H Peter, Alvarez Osvaldo, Garate Jose Antonio, Latorre Ramon, Gonzalez Carlos

Abstract excerpt

The dissipation of acute acid loads by the voltage-gated proton channel (Hv1) relies on regulating the channel's open probability by the voltage and the ΔpH across the membrane (ΔpH = pHex - pHin). Using monomeric Ciona-Hv1, we asked whether ΔpH-dependent gating is produced during the voltage sensor activation or permeation pathway opening. A leftward shift of the conductance-voltage (G-V) curve was produced at...

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Identifiers

PMID: 33941706
DOI: 10.1073/pnas.2025556118
PMCID: PMC8126849

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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