Article
Role of carcinogen-modified deoxynucleotide precursors in mutagenesis.
Mutation research - 1 Jan 2000
Snow E T, Mitra S
Abstract excerpt
Agents which damage or modify cellular DNA will generally also modify the nucleotide precursor pools, sometimes preferentially (Topal and Baker, 1982). There are at least two different ways that incorporation of modified (possibly promutagenic) nucleotides could, theoretically, make a significant contribution to the mutations induced by these agents. Modified bases may exhibit ambiguous base pairing and produce...
Topics
- Animals
- Carcinogens
- DNA Damage
- DNA Replication
- DNA-Directed DNA Polymerase
- Deoxyribonucleotides
- Guanine
- Kinetics
- Mutation
- Structure-Activity Relationship