Article
Mutagenesis and deoxyribonucleotide pool imbalance.
Mutation research - 1 Jan 2000
Kunz B A
Abstract excerpt
Numerous studies have demonstrated that DNA-precursor pool imbalances are mutagenic and can modulate the lethality and mutagenicity of DNA-damaging agents. In addition, physical and chemical mutagens can induce alterations in DNA-precursor levels. Such findings suggest that regulation of intracellular concentrations of DNA precursors may be an important factor in environmental mutagenesis. In this article,...
Topics
- Animals
- Deoxyribonucleotides
- Homeostasis
- Humans
- Mutagens
- Mutation