Article
Allosteric Transmission along a Loosely Structured Backbone Allows a Cardiac Troponin C Mutant to Function with Only One Ca2+ Ion.
The Journal of biological chemistry - 10 Feb 2017
Marques Mayra de A, Pinto Jose Renato, Moraes Adolfo H, Iqbal Anwar, de Magalhães Mariana T Q, Monteiro Jamila, Pedrote Murilo M, Sorenson Martha M, Silva Jerson L, de Oliveira Guilherme A P
Abstract excerpt
Hypertrophic cardiomyopathy (HCM) is one of the most common cardiomyopathies and a major cause of sudden death in young athletes. The Ca2+ sensor of the sarcomere, cardiac troponin C (cTnC), plays an important role in regulating muscle contraction. Although several cardiomyopathy-causing mutations have been identified in cTnC, the limited information about their structural defects has been mapped to the HCM...
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