Article
Troponins, intrinsic disorder, and cardiomyopathy.
Biological chemistry - 1 Aug 2016
Na Insung, Kong Min J, Straight Shelby, Pinto Jose R, Uversky Vladimir N
Abstract excerpt
Cardiac troponin is a dynamic complex of troponin C, troponin I, and troponin T (TnC, TnI, and TnT, respectively) found in the myocyte thin filament where it plays an essential role in cardiac muscle contraction. Mutations in troponin subunits are found in inherited cardiomyopathies, such as hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). The highly dynamic nature of human cardiac troponin and...
Topics
- Cardiomyopathies
- Humans
- Intrinsically Disordered Proteins
- Models, Molecular
- Mutation
- Troponin C
- Troponin I
- Troponin T