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Article

Enhanced Identification of Novel Potential Variants for Appendicular Lean Mass by Leveraging Pleiotropy With Bone Mineral Density.

Frontiers in immunology - 1 Jan 2021

Peng Cheng, Liu Feng, Su Kuan-Jui, Lin Xu, Song Yu-Qian, Shen Jie, Hu Shi-Di, Chen Qiao-Cong, Yuan Hui-Hui, Li Wen-Xi, Zeng Chun-Ping, Deng Hong-Wen, Lou Hui-Ling

Abstract excerpt

Strong relationships have been found between appendicular lean mass (ALM) and bone mineral density (BMD). It may be due to a shared genetic basis, termed pleiotropy. By leveraging the pleiotropy with BMD, the aim of this study was to detect more potential genetic variants for ALM. Using the conditional false discovery rate (cFDR) methodology, a combined analysis of the summary statistics of two large independent...

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Identifiers

PMID: 33889153
DOI: 10.3389/fimmu.2021.643894
PMCID: PMC8056257

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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