Article
Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus.
Nature communications - 25 Jul 2017
Medina-Gomez Carolina, Kemp John P, Dimou Niki L, Kreiner Eskil, Chesi Alessandra, Zemel Babette S, Bønnelykke Klaus, Boer Cindy G, Ahluwalia Tarunveer S, Bisgaard Hans, Evangelou Evangelos, Heppe Denise H M, Bonewald Lynda F, Gorski Jeffrey P, Ghanbari Mohsen, Demissie Serkalem, Duque Gustavo, Maurano Matthew T, Kiel Douglas P, Hsu Yi-Hsiang, C J van der Eerden Bram, Ackert-Bicknell Cheryl, Reppe Sjur, Gautvik Kaare M, Raastad Truls, Karasik David, van de Peppel Jeroen, Jaddoe Vincent W V, Uitterlinden André G, Tobias Jonathan H, Grant Struan F A, Bagos Pantelis G, Evans David M, Rivadeneira Fernando
Abstract excerpt
Bone mineral density is known to be a heritable, polygenic trait whereas genetic variants contributing to lean mass variation remain largely unknown. We estimated the shared SNP heritability and performed a bivariate GWAS meta-analysis of total-body lean mass (TB-LM) and total-body less head bone mineral density (TBLH-BMD) regions in 10,414 children. The estimated SNP heritability is 43% (95% CI: 34-52%) for...
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