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Article

Amino acids and RagD potentiate mTORC1 activation in CD8+ T cells to confer antitumor immunity.

Journal for immunotherapy of cancer - 1 Apr 2021

Zhang Yiwen, Hu Hongrong, Liu Weiwei, Yan Shu-Mei, Li Yuzhuang, Tan Likai, Chen Yingshi, Liu Jun, Peng Zhilin, Yuan Yaochang, Huang Wenjing, Yu Fei, He Xin, Li Bo, Zhang Hui

Abstract excerpt

BACKGROUND: In the tumor microenvironment, tumor cells are able to suppress antitumor immunity by competing for essential nutrients, including amino acids. However, whether amino acid depletion modulates the activity of CD8+ tumor-infiltrating lymphocytes (TILs) is unclear. METHOD: In this study, we evaluated the roles of amino acids and the Rag complex in regulating mammalian target of rapamycin complex 1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33883257
DOI: 10.1136/jitc-2020-002137
PMCID: PMC8061841

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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