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Article

Glutaminase inhibition impairs CD8 T cell activation in STK11-/Lkb1-deficient lung cancer.

Cell metabolism - 7 Jun 2022

Best Sarah A, Gubser Patrick M, Sethumadhavan Shalini, Kersbergen Ariena, Negrón Abril Yashira L, Goldford Joshua, Sellers Katherine, Abeysekera Waruni, Garnham Alexandra L, McDonald Jackson A, Weeden Clare E, Anderson Dovile, Pirman David, Roddy Thomas P, Creek Darren J, Kallies Axel, Kingsbury Gillian, Sutherland Kate D

Abstract excerpt

The tumor microenvironment (TME) contains a rich source of nutrients that sustains cell growth and facilitate tumor development. Glucose and glutamine in the TME are essential for the development and activation of effector T cells that exert antitumor function. Immunotherapy unleashes T cell antitumor function, and although many solid tumors respond well, a significant proportion of patients do not benefit. In...

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Share to Adenocarcinoma of Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD8-Positive T-Lymphocytes

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Identifiers

PMID: 35504291
DOI: 10.1016/j.cmet.2022.04.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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