Article
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.
Science (New York, N.Y.) - 13 Jun 2008
Sancak Yasemin, Peterson Timothy R, Shaul Yoav D, Lindquist Robert A, Thoreen Carson C, Bar-Peled Liron, Sabatini David M
Abstract excerpt
The multiprotein mTORC1 protein kinase complex is the central component of a pathway that promotes growth in response to insulin, energy levels, and amino acids and is deregulated in common cancers. We find that the Rag proteins--a family of four related small guanosine triphosphatases (GTPases)--interact with mTORC1 in an amino acid-sensitive manner and are necessary for the activation of the mTORC1 pathway by...
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