Article
KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.
Nature - 16 Mar 2017
Wolfson Rachel L, Chantranupong Lynne, Wyant Gregory A, Gu Xin, Orozco Jose M, Shen Kuang, Condon Kendall J, Petri Sabrina, Kedir Jibril, Scaria Sonia M, Abu-Remaileh Monther, Frankel Wayne N, Sabatini David M
Abstract excerpt
The mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of cell growth that responds to diverse environmental signals and is deregulated in many human diseases, including cancer and epilepsy. Amino acids are a key input to this system, and act through the Rag GTPases to promote the translocation of mTORC1 to the lysosomal surface, its site of activation. Multiple protein complexes regulate...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.