Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance.

doi:10.1016/j.ccell.2016.05.016

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Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance.

Cancer cell - 11 Jul 2016

Pietrocola Federico, Pol Jonathan, Vacchelli Erika, Rao Shuan, Enot David P, Baracco Elisa E, Levesque Sarah, Castoldi Francesca, Jacquelot Nicolas, Yamazaki Takahiro, Senovilla Laura, Marino Guillermo, Aranda Fernando, Durand Sylvère, Sica Valentina, Chery Alexis, Lachkar Sylvie, Sigl Verena, Bloy Norma, Buque Aitziber, Falzoni Simonetta, Ryffel Bernhard, Apetoh Lionel, Di Virgilio Francesco, Madeo Frank, Maiuri Maria Chiara, Zitvogel Laurence, Levine Beth, Penninger Josef M, Kroemer Guido

Abstract excerpt

Caloric restriction mimetics (CRMs) mimic the biochemical effects of nutrient deprivation by reducing lysine acetylation of cellular proteins, thus triggering autophagy. Treatment with the CRM hydroxycitrate, an inhibitor of ATP citrate lyase, induced the depletion of regulatory T cells (which dampen anticancer immunity) from autophagy-competent, but not autophagy-deficient, mutant KRAS-induced lung cancers in...

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PMID: 27411589
DOI: 10.1016/j.ccell.2016.05.016
PMCID: PMC5715805

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KRAS

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