Cis-epistasis at the LPA locus and risk of cardiovascular diseases.

doi:10.1093/cvr/cvab136

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Article

Cis-epistasis at the LPA locus and risk of cardiovascular diseases.

Cardiovascular research - 16 Mar 2022

Zeng Lingyao, Moser Sylvain, Mirza-Schreiber Nazanin, Lamina Claudia, Coassin Stefan, Nelson Christopher P, Annilo Tarmo, Franzén Oscar, Kleber Marcus E, Mack Salome, Andlauer Till F M, Jiang Beibei, Stiller Barbara, Li Ling, Willenborg Christina, Munz Matthias, Kessler Thorsten, Kastrati Adnan, Laugwitz Karl-Ludwig, Erdmann Jeanette, Moebus Susanne, Nöthen Markus M, Peters Annette, Strauch Konstantin, Müller-Nurasyid Martina, Gieger Christian, Meitinger Thomas, Steinhagen-Thiessen Elisabeth, März Winfried, Metspalu Andres, Björkegren Johan L M, Samani Nilesh J, Kronenberg Florian, Müller-Myhsok Bertram, Schunkert Heribert

Abstract excerpt

AIMS: Coronary artery disease (CAD) has a strong genetic predisposition. However, despite substantial discoveries made by genome-wide association studies (GWAS), a large proportion of heritability awaits identification. Non-additive genetic effects might be responsible for part of the unaccounted genetic variance. Here, we attempted a proof-of-concept study to identify non-additive genetic effects, namely...

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Identifiers

PMID: 33878186
DOI: 10.1093/cvr/cvab136
PMCID: PMC8930071

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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