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Article

Genome-Wide Pleiotropy Analysis Identifies Shared and Opposing Pathways Influencing Coronary Artery Disease and Cancer.

Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2025

Yarmolinsky James, Lau Evelyn, Koskeridis Fotios, Gunter Marc J, Wang Dennis, Dehghan Abbas, Tzoulaki Ioanna

Abstract excerpt

BACKGROUND: Coronary artery disease (CAD) and cancer are 2 leading global causes of mortality, with shared modifiable risk factors, yet the genetic and molecular mechanisms underlying their comorbidity remain poorly understood. METHODS: We performed a genome-wide pleiotropy analysis to identify shared genetic mechanisms across CAD and 4 common cancers that share modifiable risk factors with CAD (breast,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40874306
DOI: 10.1161/ATVBAHA.125.322433
PMCID: PMC12453103

Genes

CAD
ANGPTL4
CALCRL
LAMC1
MYO9B
TERT

Provenance

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