Article

<i>Cis</i> -epistasis at the <i>LPA</i> locus and risk of coronary artery disease

2019-01-23

Abstract excerpt

Identification of epistasis affecting complex human traits has been challenging. Focusing on known coronary artery disease (CAD) risk loci, we explore pairwise statistical interactions between 8,068 SNPs from ten CAD genome-wide association studies (n=30,180). We discovered rs1800769 and rs9458001 in the vicinity of the LPA locus to interact in modulating CAD risk (P=1.75×10 −13 ). Specific genotypes (e.g., rs18...

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Literature Corpus work: bb307fe3-73b2-544a-9817-db7074ea9fe0
DOI: 10.1101/518290

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