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Cardiovascular Implications of Lipoprotein(a) and its Genetic Variants

1 Jul 2025

Abstract excerpt

Dyslipidemia, a significant risk factor for cardiovascular diseases (CVDs), is prevalent in the Middle East (ME) countries. With a variable prevalence, elevated lipoprotein (a) [Lp(a)] is the most widespread monogenic dyslipidemic disorder. Genetic studies have established Lp(a) as a heritable and independent risk factor for CVD. This discovery has shifted the perception of Lp(a) and the LPA gene from mere...

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PMID: 40610121
DOI: 10.1016/j.jacasi.2025.04.012

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