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Article

The effect of LPA Thr3888Pro on lipoprotein(a) and coronary artery disease is modified by the LPA KIV-2 variant 4925G>A.

Atherosclerosis - 1 May 2022

Grüneis Rebecca, Lamina Claudia, Di Maio Silvia, Schönherr Sebastian, Zoescher Peter, Forer Lukas, Streiter Gertraud, Peters Annette, Gieger Christian, Köttgen Anna, Kronenberg Florian, Coassin Stefan

Abstract excerpt

BACKGROUND AND AIMS: High lipoprotein(a) [Lp(a)] concentrations are associated with increased coronary artery disease (CAD) risk. Lp(a) is regulated mainly genetically by the LPA gene but involved genetic variants have not been fully elucidated. Improved understanding of the entanglements of genetic Lp(a) regulation may enhance genetic prediction of Lp(a) and CAD risk. We investigated an interaction between the...

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Identifiers

PMID: 35534298
DOI: 10.1016/j.atherosclerosis.2022.04.023
PMCID: PMC7613586

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