Article
Evidence for several independent genetic variants affecting lipoprotein (a) cholesterol levels.
Human molecular genetics - 15 Apr 2015
Lu Wensheng, Cheng Yu-Ching, Chen Keping, Wang Hong, Gerhard Glenn S, Still Christopher D, Chu Xin, Yang Rongze, Parihar Ankita, O'Connell Jeffrey R, Pollin Toni I, Angles-Cano Eduardo, Quon Michael J, Mitchell Braxton D, Shuldiner Alan R, Fu Mao
Abstract excerpt
Lipoprotein (a) [Lp(a)] is an independent risk factor for atherosclerosis-related events that is under strong genetic control (heritability = 0.68-0.98). However, causal mutations and functional validation of biological pathways modulating Lp(a) metabolism are lacking. We performed a genome-wide association scan to identify genetic variants associated with Lp(a)-cholesterol levels in the Old Order Amish. We...
Topics
- Adult
- Aged
- Atherosclerosis
- Cholesterol
- Chromosomes, Human, Pair 6
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Genotype
- Humans