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Article

Universal Constraints on Protein Evolution in the Long-Term Evolution Experiment with Escherichia coli.

Genome biology and evolution - 8 Jun 2021

Maddamsetti Rohan

Abstract excerpt

Although it is well known that abundant proteins evolve slowly across the tree of life, there is little consensus for why this is true. Here, I report that abundant proteins evolve slowly in the hypermutator populations of Lenski's long-term evolution experiment with Escherichia coli (LTEE). Specifically, the density of all observed mutations per gene, as measured in metagenomic time series covering 60,000...

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Identifiers

PMID: 33856016
DOI: 10.1093/gbe/evab070
PMCID: PMC8233687

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