Idiosyncratic Purifying Selection on Metabolic Enzymes in the Long-Term Evolution Experiment with Escherichia coli.

Abstract excerpt

Bacteria, Archaea, and Eukarya all share a common set of metabolic reactions. This implies that the function and topology of central metabolism has been evolving under purifying selection over deep time. Central metabolism may similarly evolve under purifying selection during long-term evolution experiments, although it is unclear how long such experiments would have to run (decades, centuries, millennia) before...

Topics

• Child
• Humans
• Escherichia coli
• Metabolic Networks and Pathways
• Mutation
• Genome
• Archaea
• Evolution, Molecular
• Selection, Genetic