Article
The landscape of transcriptional and translational changes over 22 years of bacterial adaptation.
eLife - 10 Oct 2022
Favate John S, Liang Shun, Cope Alexander L, Yadavalli Srujana S, Shah Premal
Abstract excerpt
Organisms can adapt to an environment by taking multiple mutational paths. This redundancy at the genetic level, where many mutations have similar phenotypic and fitness effects, can make untangling the molecular mechanisms of complex adaptations difficult. Here, we use the Escherichia coli long-term evolution experiment (LTEE) as a model to address this challenge. To understand how different genomic changes...
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