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Article

Essentiality Is a Strong Determinant of Protein Rates of Evolution during Mutation Accumulation Experiments in Escherichia coli.

Genome biology and evolution - 26 Sept 2016

Alvarez-Ponce David, Sabater-Muñoz Beatriz, Toft Christina, Ruiz-González Mario X, Fares Mario A

Abstract excerpt

The Neutral Theory of Molecular Evolution is considered the most powerful theory to understand the evolutionary behavior of proteins. One of the main predictions of this theory is that essential proteins should evolve slower than dispensable ones owing to increased selective constraints. Comparison of genomes of different species, however, has revealed only small differences between the rates of evolution of...

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Identifiers

PMID: 27566759
DOI: 10.1093/gbe/evw205
PMCID: PMC5630975

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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