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Article

Purifying selection enduringly acts on the sequence evolution of highly expressed proteins in Escherichia coli.

G3 (Bethesda, Md.) - 4 Nov 2022

Shibai Atsushi, Kotani Hazuki, Sakata Natsue, Furusawa Chikara, Tsuru Saburo

Abstract excerpt

The evolutionary speed of a protein sequence is constrained by its expression level, with highly expressed proteins evolving relatively slowly. This negative correlation between expression levels and evolutionary rates (known as the E-R anticorrelation) has already been widely observed in past macroevolution between species from bacteria to animals. However, it remains unclear whether this seemingly general law...

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PMID: 36073932
DOI: 10.1093/g3journal/jkac235
PMCID: PMC9635659

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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