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Article

Selection Maintains Protein Interactome Resilience in the Long-Term Evolution Experiment with Escherichia coli.

Genome biology and evolution - 8 Jun 2021

Maddamsetti Rohan

Abstract excerpt

Most cellular functions are carried out by a dynamic network of interacting proteins. An open question is whether the network properties of protein interactomes represent phenotypes under natural selection. One proposal is that protein interactomes have evolved to be resilient, such that they tend to maintain connectivity when proteins are removed from the network. This hypothesis predicts that interactome...

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PMID: 33878164
DOI: 10.1093/gbe/evab074
PMCID: PMC8214405

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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