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Synonymous Genetic Variation in Natural Isolates of Escherichia coli Does Not Predict Where Synonymous Substitutions Occur in a Long-Term Experiment.

Molecular biology and evolution - 1 Nov 2015

Maddamsetti Rohan, Hatcher Philip J, Cruveiller Stéphane, Médigue Claudine, Barrick Jeffrey E, Lenski Richard E

Abstract excerpt

Synonymous genetic differences vary by more than 20-fold among genes in natural isolates of Escherichia coli. One hypothesis to explain this heterogeneity is that genes with high levels of synonymous variation mutate at higher rates than genes with low synonymous variation. If so, then one would expect to observe similar mutational patterns in evolution experiments. In fact, however, the pattern of synonymous...

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PMID: 26199375
DOI: 10.1093/molbev/msv161
PMCID: PMC4651231

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