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Article

Discovery of positive and purifying selection in metagenomic time series of hypermutator microbial populations.

PLoS genetics - 1 Aug 2022

Maddamsetti Rohan, Grant Nkrumah A

Abstract excerpt

A general method to infer both positive and purifying selection during the real-time evolution of hypermutator pathogens would be broadly useful. To this end, we introduce a Simple Test to Infer Mode of Selection (STIMS) from metagenomic time series of evolving microbial populations. We test STIMS on metagenomic data generated by simulations of bacterial evolution, and on metagenomic data spanning 62,750...

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PMID: 35981004
DOI: 10.1371/journal.pgen.1010324
PMCID: PMC9426924

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