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Article

Tissue-specific cell-free DNA degradation quantifies circulating tumor DNA burden.

Nature communications - 13 Apr 2021

Zhu Guanhua, Guo Yu A, Ho Danliang, Poon Polly, Poh Zhong Wee, Wong Pui Mun, Gan Anna, Chang Mei Mei, Kleftogiannis Dimitrios, Lau Yi Ting, Tay Brenda, Lim Wan Jun, Chua Clarinda, Tan Tira J, Koo Si-Lin, Chong Dawn Q, Yap Yoon Sim, Tan Iain, Ng Sarah, Skanderup Anders J

Abstract excerpt

Profiling of circulating tumor DNA (ctDNA) may offer a non-invasive approach to monitor disease progression. Here, we develop a quantitative method, exploiting local tissue-specific cell-free DNA (cfDNA) degradation patterns, that accurately estimates ctDNA burden independent of genomic aberrations. Nucleosome-dependent cfDNA degradation at promoters and first exon-intron junctions is strongly associated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33850132
DOI: 10.1038/s41467-021-22463-y
PMCID: PMC8044092

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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