Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Directed Evolution of Stabilized Monomeric CD19 for Monovalent CAR Interaction Studies and Monitoring of CAR-T Cell Patients.

ACS synthetic biology - 21 May 2021

Laurent Elisabeth, Sieber Anna, Salzer Benjamin, Wachernig Anna, Seigner Jacqueline, Lehner Manfred, Geyeregger René, Kratzer Bernhard, Jäger Ulrich, Kunert Renate, Pickl Winfried F, Traxlmayr Michael W

Abstract excerpt

CD19 is among the most relevant targets in cancer immunotherapy. However, its extracellular domain (ECD) is prone to aggregation and misfolding, representing a major obstacle for the development and analysis of CD19-targeted therapeutics. Here, we engineered stabilized CD19-ECD (termed SuperFolder) variants, which also showed improved expression rates and, in contrast to the wild type protein, they could be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD19
Share to Directed Molecular Evolution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunotherapy, Adoptive

Share to Lymphoma, Large B-Cell, Diffuse

Share to Mutant Proteins

Share to Protein Domains

Share to Protein Stability

Share to Receptors, Chimeric Antigen

Source

Open in PubMed Open full text

Identifiers

PMID: 33843201
DOI: 10.1021/acssynbio.1c00010
PMCID: PMC8155657

Genes

CD19
ECD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Directed Evolution of Stabilized Monomeric CD19 for Monovalent CAR Interaction Studies and Monitoring of CAR-T Cell Patients.PMID 33843201Read ↗

Fine Epitope Mapping of the CD19 Extracellular Domain Promotes Design.Semantic proximity Read ↗

Characterization of novel CD19-specific VHHs isolated from a camelid immune library by phage displaySemantic proximity Read ↗

Computational modeling and optimization of peptide-based CAR-T cell receptors targeting CD19 for enhanced efficacy and minimized toxicitySemantic proximity Read ↗

MiniCARbids: Minimalistic human binding domains specifically tailored to CAR T applicationsSemantic proximity Read ↗

CAR therapy: the CD19 paradigmSemantic proximity Read ↗

Unique Binding and Stabilization Mechanisms Employed By and Engineered Into NanobodiesSemantic proximity Read ↗

On the humanization of VHHs: Prospective case studies, experimental and computational characterization of structural determinants for functionalitySemantic proximity Read ↗

Design of solubly expressed miniaturized SMART MHCsSemantic proximity Read ↗

Humanization of the anti-CD18 antibody 6.7: an unexpected effect of a framework residue in binding to antigen.Semantic proximity Read ↗

Development of a Functional Antibody by Using a Green Fluorescent Protein Frame as the TemplateSemantic proximity Read ↗

Engineering B cells to express fully customizable antibodies with enhanced Fc functions.Semantic proximity Read ↗

A single-domain antibody library based on a stability-engineered human VH3 scaffoldSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.