Article
MiniCARbids: Minimalistic human binding domains specifically tailored to CAR T applications
2025-09-13
Abstract excerpt
Traditionally, chimeric antigen receptor (CAR) T cells employ single-chain variable fragments (scFvs) as binding entities. While scFvs represent a convenient option due to their broad availability, they also come with drawbacks, in particular their tendency to cluster and their relatively large size. Moreover, most scFvs used in the CAR field are of non-human origin, potentially causing immunogenicity. Therefore,...
Topics
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- Advanced Biosensing Techniques and Applications
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Nanowire Synthesis and Applications
- Phagocytosis and Immune Regulation
- Viral Infectious Diseases and Gene Expression in Insects
- Virus-based gene therapy research
Identifiers and source
- Literature Corpus work
- 1b15c5a3-3f31-5b3b-92ef-5bf63ee4272d
- DOI
- 10.1101/2025.09.09.675083