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A single-domain antibody library based on a stability-engineered human VH3 scaffold

31 Jul 2024

Abstract excerpt

Using conventional immunoglobulin G (IgG) molecules as therapeutic agents presents several well-known disadvantages owing to their large size and structural complexity, negatively impacting development and production efficiency. Single-domain antibodies (sdAbs) are the smallest functional antibody format (~ 15 kDa) and represent a viable alternative to IgG in many applications. However, unlike natural...

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Glycosylation and Glycoproteins Research
Monoclonal and Polyclonal Antibodies Research
Protein purification and stability

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39085444
DOI: 10.1038/s41598-024-68680-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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