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Article

Fine Epitope Mapping of the CD19 Extracellular Domain Promotes Design.

Biochemistry - 3 Dec 2019

Klesmith Justin R, Wu Lan, Lobb Roy R, Rennert Paul D, Hackel Benjamin J

Abstract excerpt

The B-cell surface protein CD19 is present throughout the cell life cycle and is uniformly expressed in leukemias, making it a target for chimeric antigen receptor engineered immune cell therapy. Identifying the sequence dependence of the binding of CD19 to antibodies empowers fundamental study and more tailored development of CD19-targeted therapeutics. To identify the antibody-binding epitopes on CD19, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31702909
DOI: 10.1021/acs.biochem.9b00808

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