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Article

Humanization of the anti-CD18 antibody 6.7: an unexpected effect of a framework residue in binding to antigen.

Molecular immunology - 1 May 2003

Caldas Cristina, Coelho Verônica, Kalil Jorge, Moro Ana Maria, Maranhão Andrea Q, Brígido Marcelo M

Abstract excerpt

Humanization of monoclonal antibodies by complementary determinant region (CDR)-grafting has become a standard procedure to improve the clinical usage of animal antibodies. However, antibody humanization may result in loss of activity that has been attributed to structural constraints in the framework structure. In this paper, we report the complete humanization of the 6.7 anti-human CD18 monoclonal antibody in a...

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Source

Identifiers

PMID: 12695120
DOI: 10.1016/s0161-5890(03)00022-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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