Article
Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein.
The Journal of biological chemistry - 4 Jul 2003
Sato Toru, Dohmae Naoshi, Qi Yue, Kakuda Nobuto, Misonou Hiroaki, Mitsumori Rie, Maruyama Hiroko, Koo Edward H, Haass Christian, Takio Koji, Morishima-Kawashima Maho, Ishiura Shoichi, Ihara Yasuo
Abstract excerpt
A novel cleavage of beta-amyloid precursor protein (APP), referred to as epsilon-cleavage, occurs downstream of the gamma-cleavage and generates predominantly a C-terminal fragment (CTFgamma) that begins at Val-50, according to amyloid beta-protein (Abeta) numbering. Whether this cleavage occurs independently of, or is coordinated with, gamma-cleavage is unknown. Using a cell-free system, we show here that,...
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