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Article

Enhanced amyloid-β generation by γ-secretase complex in DRM microdomains with reduced cholesterol levels.

Human molecular genetics - 1 Feb 2020

Hata Saori, Hu Anqi, Piao Yi, Nakaya Tadashi, Taru Hidenori, Morishima-Kawashima Maho, Murayama Shigeo, Nishimura Masaki, Suzuki Toshiharu

Abstract excerpt

A neuropathologic hallmark of Alzheimer's disease (AD) is the presence of senile plaques that contain neurotoxic amyloid-β protein (Aβ) species, which are generated by the cleavage of amyloid β-protein precursor by secretases such as the γ-secretase complex, preferentially located in detergent-resistant membrane (DRM) regions and comprising endoproteolysed amino- and carboxy-terminal fragments of presenilin,...

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Identifiers

PMID: 31841137
DOI: 10.1093/hmg/ddz297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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