Article
Accurate estimation of SNP-heritability from biobank-scale data irrespective of genetic architecture
2019-01-23
Abstract excerpt
The proportion of phenotypic variance attributable to the additive effects of a given set of genotyped SNPs (i.e. SNP-heritability) is a fundamental quantity in the study of complex traits. Recent works have shown that existing methods to estimate genome-wide SNP-heritability often yield biases when their assumptions are violated. While various approaches have been proposed to account for frequency- and LD-depende...
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Identifiers and source
- Literature Corpus work
- ca8a02ab-0610-5205-b30f-41d485c1ce1a
- DOI
- 10.1101/526855